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Target
Lysine-specific demethylase 4C
Ligand
BDBM264046
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Inhibition Assay
IC50
550±n/a nM
Citation
 Nie, Z; Stafford, JA; Veal, JM; Wallace, MB Histone demethylase inhibitors US Patent  US9908865 Publication Date 3/6/2018 
Target
Name:
Lysine-specific demethylase 4C
Synonyms:
GASC-1 protein | GASC1 | Gene amplified in squamous cell carcinoma 1 protein | JHDM3C | JMJD2C | JmjC domain-containing histone demethylation protein 3C | Jumonji domain-containing protein 2C | KDM4C | KDM4C_HUMAN | KIAA0780
Type:
Protein
Mol. Mass.:
119979.01
Organism:
Homo sapiens (Human)
Description:
Q9H3R0
Residue:
1056
Sequence:
MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLEPGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQGERKRQRVLSSRFKNEYVADPVYRTFLKSSFQKKCQKRQ
  
Inhibitor
Name:
BDBM264046
Synonyms:
2-[5-[(2-fluoro-4- methylphenyl)methoxy]pyrazol-1- yl]pyridine-4-carboxylic acid | US10173996, Example 131 | US9604961, Example 131 | US9714230, 131 | US9908865, Example 131
Type:
Small organic molecule
Emp. Form.:
C17H14FN3O3
Mol. Mass.:
327.3098
SMILES:
Cc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)c(F)c1
Structure:
Search PDB for entries with ligand similarity: