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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM261869
Substrate
n/a
Meas. Tech.
Test for Antagonism
Temperature
298.15±n/a K
IC50
43.7±n/a nM
Comments
extracted
Citation
 Peters, O; Bräuer, N; Blume, T; Ter Laak, A; Zorn, L; Nagel, J; Kaulfuss, S; Langer, G; Kuhnke, J Benzimidazole derivatives as EP4 antagonists US Patent  US9708311 Publication Date 7/18/2017 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM261869
Synonyms:
1-(2-Methoxyethyl)-2-[9-(prop-2-yn-1-yl)-9H-carbazol-3-yl]-1H-benzimidazole-5-carboxylic acid | US9708311, 119
Type:
Small organic molecule
Emp. Form.:
C26H21N3O3
Mol. Mass.:
423.4632
SMILES:
COCCn1c(nc2cc(ccc12)C(O)=O)-c1ccc2n(CC#C)c3ccccc3c2c1
Structure:
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