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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM380592
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
623±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9926330 Publication Date 3/27/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM380592
Synonyms:
4-((trans)-4-(((6-methylquinazolin-4-yl)amino)cyclohexyl)thiomorpholine-1,1-dioxide | US9926330, 6-1
Type:
Small organic molecule
Emp. Form.:
C19H26N4O2S
Mol. Mass.:
374.5
SMILES:
Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCS(=O)(=O)CC3)c2c1 |r,wU:13.16,wD:10.9,(;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;6.67,-.77,;5.33,,;5.33,1.54,;6.67,2.31,;8,1.54,;9.34,2.31,;9.34,3.85,;8,4.62,;6.67,3.85,;10.67,4.62,;10.67,6.16,;12,6.93,;13.34,6.16,;14.15,7.47,;14.88,6.21,;13.34,4.62,;12,3.85,;4,-.77,;2.67,,)|
Structure:
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