Reaction Details Report a problem with these data
Target
G-protein coupled receptor 6
Ligand
BDBM382124
Substrate
n/a
Meas. Tech.
A.1 Inhibition of cAMP Activity of GPR6 In Vitro Assay
EC50
13700±n/a nM
Citation
 Adams, ME; Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Lam, B; Monenschein, H; Reichard, H; Sun, H Pyrazines as modulators of GPR6 US Patent  US10273225 Publication Date 4/30/2019 
Target
Name:
G-protein coupled receptor 6
Synonyms:
G-protein coupled receptor 6 (GPR6) | GPR6 | GPR6_HUMAN | Sphingosine 1-phosphate receptor GPR6
Type:
Protein
Mol. Mass.:
37886.39
Organism:
Homo sapiens (Human)
Description:
P46095
Residue:
362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
  
Inhibitor
Name:
BDBM382124
Synonyms:
6-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(isopropylamino)-3-(methoxy methyl)pyrazine-2-carbonitrile | US10000468, Example 33 | US10273225, Example 33
Type:
Small organic molecule
Emp. Form.:
C21H25F2N5O2
Mol. Mass.:
417.4523
SMILES:
COCc1nc(NC(C)C)c(nc1C#N)N1CCC(CC1)Oc1ccc(F)cc1F
Structure:
Search PDB for entries with ligand similarity: