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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384575
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
5.00±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384575
Synonyms:
4-({trans-4-[(2R,6S)-2,6- dimethylmorpholin-4- yl]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 3-9
Type:
Small organic molecule
Emp. Form.:
C21H27N5O
Mol. Mass.:
365.472
SMILES:
C[C@H]1CN(C[C@@H](C)O1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:11.15,5.5,1.0,wD:8.8,(5.78,2.67,;4.23,2.67,;3.47,1.33,;1.93,1.33,;1.15,2.67,;1.93,4,;1.15,5.33,;3.47,4,;1.15,,;-.38,,;-1.15,-1.33,;-.38,-2.67,;1.15,-2.67,;1.93,-1.33,;-1.15,-4,;-2.69,-4,;-3.47,-5.33,;-5,-5.33,;-5.78,-4,;-5,-2.67,;-5.78,-1.33,;-5,,;-3.47,,;-2.69,-1.33,;-3.47,-2.67,;-2.69,1.33,;-1.93,2.67,)|
Structure:
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