Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM386398
Substrate
n/a
Meas. Tech.
Human Factor D Assay
IC50
<1000±n/a nM
Citation
Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders US Patent US10287301 Publication Date 5/14/2019
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM386398
Synonyms:
(2S,4R)-1-(2-(3- acetyl-6-hydroxy-5- (2-methylpyrimidin-5- yl)-1H-indol-1- yl)acetyl)-N-(6- bromopyridin-2- yl)-4- fluoropyrrolidine-2- carboxamide | US10287301, Compound 328 | US10822352, Comp No. 328
Type:
Small organic molecule
Emp. Form.:
C27H24BrFN6O4
Mol. Mass.:
595.42
SMILES:
CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2cc(O)c(cc12)-c1cnc(C)nc1 |r|