Reaction Details Report a problem with these data
Target
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Ligand
BDBM26433
Substrate
BDBM26431
Meas. Tech.
MurD Inhibition Assay
pH
8.6±n/a
Temperature
310.15±n/a K
Comments
76% residual activity in the presence of 1 mM inhibitor.
Citation
Humljan, J; Kotnik, M; Contreras-Martel, C; Blanot, D; Urleb, U; Dessen, A; Solmajer, T; Gobec, S Novel Naphthalene-N-sulfonyl-d-glutamic Acid Derivatives as Inhibitors of MurD, a Key Peptidoglycan Biosynthesis Enzyme. J Med Chem 51:7486-94 (2008) [PubMed] Article
Target
Name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Synonyms:
D-glutamic acid-adding enzyme | MURD_ECOLI | MurD (E. coli) | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | murD
Type:
Ligase
Mol. Mass.:
46963.02
Organism:
Escherichia coli (strain K12)
Description:
n/a
Residue:
438
Sequence:
MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHLNHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG
Inhibitor
Name:
BDBM26433
Synonyms:
(2R)-2-[2-(naphthalen-2-yloxy)acetamido]pentanedioic acid | carboxamide, 5c
Type:
Small organic molecule
Emp. Form.:
C17H17NO6
Mol. Mass.:
331.32
SMILES:
OC(=O)CC[C@@H](NC(=O)COc1ccc2ccccc2c1)C(O)=O |r|