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Target
NAD-dependent protein deacetylase sirtuin-2
Ligand
BDBM29059
Substrate
Fluor de Lys-SIRT2
Meas. Tech.
Enzyme Inhibition Assay
IC50
4800±n/a nM
Citation
 Medda, F; Russell, RJ; Higgins, M; McCarthy, AR; Campbell, J; Slawin, AM; Lane, DP; Lain, S; Westwood, NJ Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity. J Med Chem 52:2673-82 (2009) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-2
Synonyms:
NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:
Hydrolase
Mol. Mass.:
43172.62
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
  
Inhibitor
Name:
BDBM29059
Synonyms:
cambinol analog, 6h
Type:
Small organic molecule
Emp. Form.:
C24H22N2O2S
Mol. Mass.:
402.509
SMILES:
CCCn1c(-c2ccccc2)c(Cc2c(O)ccc3ccccc23)c(=O)[nH]c1=S
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Fluor de Lys-SIRT2
Synonyms:
n/a
Type:
fluorogenic, acetylated peptide
Mol. Mass.:
1457.67
Organism:
n/a
Description:
Based on residues 317-320 of p53.
Residue:
13
Sequence:
GLNPRLYSLYSAC