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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM394053
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
1.000±n/a nM
Citation
 Altman, MD; Andresen, BM; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Torres, L Inhibitors of IRAK4 activity US Patent  US9969749 Publication Date 5/15/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM394053
Synonyms:
5-[4-({trans-4- [cyclopropyl(methyl)amino] cyclohexyl}amino) quinazolin-6-yl]pyridin-3- ol | US9969749, Example 5-3
Type:
Small organic molecule
Emp. Form.:
C23H27N5O
Mol. Mass.:
389.4934
SMILES:
CN(C1CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncc(O)c1 |r,wU:5.5,wD:8.12,(4.62,-5.23,;3.08,-5.23,;2.31,-6.57,;.98,-7.34,;2.31,-8.11,;2.31,-3.9,;.77,-3.9,;,-2.56,;.77,-1.23,;2.31,-1.23,;3.08,-2.56,;,.1,;-1.54,.1,;-2.31,-1.23,;-3.85,-1.23,;-4.62,.1,;-3.85,1.44,;-4.62,2.77,;-3.85,4.1,;-2.31,4.1,;-1.54,2.77,;-2.31,1.44,;-1.54,5.44,;-2.31,6.77,;-1.54,8.11,;,8.11,;.77,6.77,;2.31,6.77,;,5.44,)|
Structure:
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