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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM394078
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
1.000±n/a nM
Citation
 Altman, MD; Andresen, BM; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Torres, L Inhibitors of IRAK4 activity US Patent  US9969749 Publication Date 5/15/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM394078
Synonyms:
US9969749, Example 5-28 | cyclopropyl{4-[trans-4- ({6-[6-fluoro-5- (methylamino)pyridin-3- yl]quinazolin-4- yl}amino)cyclohexyl] piperazin-1-yl}methanone
Type:
Small organic molecule
Emp. Form.:
C28H34FN7O
Mol. Mass.:
503.6143
SMILES:
CNc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCN(CC3)C(=O)C3CC3)c2c1 |r,wU:21.25,wD:18.18,(1.26,6,;.49,7.34,;-1.05,7.34,;-1.82,6,;-3.36,6,;-4.13,7.34,;-3.36,8.67,;-1.82,8.67,;-1.05,10,;-4.13,4.67,;-5.67,4.67,;-6.44,3.33,;-5.67,2,;-6.44,.67,;-5.67,-.67,;-4.13,-.67,;-3.36,.67,;-1.82,.67,;-1.05,-.67,;-1.82,-2,;-1.05,-3.33,;.49,-3.33,;1.26,-2,;.49,-.67,;1.26,-4.67,;.49,-6,;1.26,-7.34,;2.8,-7.34,;3.57,-6,;2.8,-4.67,;3.57,-8.67,;2.8,-10,;5.11,-8.67,;6.44,-9.44,;6.44,-7.9,;-4.13,2,;-3.36,3.33,)|
Structure:
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