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Target
Alpha-2C adrenergic receptor
Ligand
BDBM398507
Substrate
n/a
Meas. Tech.
Antagonism Against Adrenoreceptors
IC50
82.0±n/a nM
Citation
 Becker-Pelster, EM; Buchgraber, P; Buchmüller, A; Engel, K; Geiss, V; Göller, A; Himmel, H; Kast, R; Knorr, A; Lang, D; Redlich, G; Schmeck, C; Tinel, H; Wunder, F Substituted piperidinyl tetrahydroquinolines US Patent  US10323020 Publication Date 6/18/2019 
Target
Name:
Alpha-2C adrenergic receptor
Synonyms:
ADA2C_HUMAN | ADRA2C | ADRA2L2 | ADRA2RL2 | Adrenergic alpha2C | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2C-, receptor | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | adrenergic, alpha-2C-, receptor [Homo sapiens]
Type:
Enzyme
Mol. Mass.:
49552.32
Organism:
Homo sapiens (Human)
Description:
P18825
Residue:
462
Sequence:
MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
  
Inhibitor
Name:
BDBM398507
Synonyms:
US10323020, Example 1 | [4-(3,4-Dihydroisoquinolin-2(1H)-yl)piperidin-1-yl]{2-[(2-methoxyethyl)amino]pyrimidin-5-yl}methanone
Type:
Small organic molecule
Emp. Form.:
C22H29N5O2
Mol. Mass.:
395.498
SMILES:
COCCNc1ncc(cn1)C(=O)N1CCC(CC1)N1CCc2ccccc2C1
Structure:
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