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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Ligand
BDBM399926
Substrate
n/a
Meas. Tech.
cintillation Proximity Assay (SPA)
IC50
44.3±n/a nM
Citation
 Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Hayward, MM 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds US Patent  US10323042 Publication Date 6/18/2019 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B)
Type:
Protein
Mol. Mass.:
83318.87
Organism:
Homo sapiens (Human)
Description:
Q07343
Residue:
736
Sequence:
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM399926
Synonyms:
(6S)-3-(4-Chloro-2-methylphenyl)-N-cyclopropyl-6-fluoro-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide | US10323042, Example 6 | US10738063, Example 6
Type:
Small organic molecule
Emp. Form.:
C17H17ClFN3O2
Mol. Mass.:
349.787
SMILES:
Cc1cc(Cl)ccc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1 |r,wD:13.14,(-13.69,-21.89,;-12.21,-21.49,;-11.81,-20.01,;-10.32,-19.61,;-9.92,-18.12,;-9.23,-20.7,;-9.63,-22.18,;-11.12,-22.58,;-11.52,-24.07,;-10.61,-25.32,;-11.52,-26.56,;-12.98,-26.09,;-14.31,-26.86,;-15.65,-26.09,;-16.98,-26.86,;-15.65,-24.55,;-14.31,-23.78,;-12.98,-24.55,;-9.07,-25.32,;-8.3,-23.98,;-8.3,-26.65,;-6.76,-26.65,;-5.43,-27.42,;-5.43,-25.88,)|
Structure:
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