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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM399968
Substrate
n/a
Meas. Tech.
cintillation Proximity Assay (SPA)
IC50
63.8±n/a nM
Citation
 Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Hayward, MM 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds US Patent  US10323042 Publication Date 6/18/2019 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE1 | NP_000914.2 | PDE21 | PDE4C | PDE4C1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
79875.54
Organism:
Homo sapiens (Human)
Description:
Q08493
Residue:
712
Sequence:
MENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERDLSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT
  
Inhibitor
Name:
BDBM399968
Synonyms:
US10323042, Example 48 | US10738063, Example 48
Type:
Small organic molecule
Emp. Form.:
C17H17ClFN3O2
Mol. Mass.:
349.787
SMILES:
Cc1cc(Cl)c(F)cc1-c1c2OCCCn2nc1C(=O)N1CCC1 |(-2.46,1.44,;-.98,1.83,;-.58,3.32,;.91,3.72,;1.31,5.21,;2,2.63,;3.49,3.03,;1.6,1.14,;.11,.75,;-.29,-.74,;-1.75,-1.22,;-3.08,-.45,;-4.42,-1.22,;-4.42,-2.76,;-3.08,-3.53,;-1.75,-2.76,;-.29,-3.23,;.62,-1.99,;2.16,-1.99,;2.93,-.65,;2.93,-3.32,;2.53,-4.81,;4.02,-5.21,;4.42,-3.72,)|
Structure:
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