Reaction Details Report a problem with these data
Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM399979
Substrate
n/a
Meas. Tech.
cintillation Proximity Assay (SPA)
IC50
16.4±n/a nM
Citation
 Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Hayward, MM 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds US Patent  US10323042 Publication Date 6/18/2019 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE1 | NP_000914.2 | PDE21 | PDE4C | PDE4C1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
79875.54
Organism:
Homo sapiens (Human)
Description:
Q08493
Residue:
712
Sequence:
MENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERDLSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT
  
Inhibitor
Name:
BDBM399979
Synonyms:
US10323042, Example 58
Type:
Small organic molecule
Emp. Form.:
C16H12ClF4N3O2
Mol. Mass.:
389.732
SMILES:
Fc1cc(-c2c3OCC(F)(F)Cn3nc2C(=O)NC2CC2)c(F)cc1Cl |(3.46,2.47,;1.97,2.07,;1.57,.59,;.09,.19,;-.31,-1.3,;-1.78,-1.78,;-3.11,-1.01,;-4.44,-1.78,;-4.44,-3.32,;-5.78,-4.09,;-4.44,-4.86,;-3.11,-4.09,;-1.78,-3.32,;-.31,-3.79,;.59,-2.55,;2.13,-2.55,;2.9,-1.21,;2.9,-3.88,;4.44,-3.88,;5.78,-4.65,;5.78,-3.11,;-1,1.28,;-2.49,.88,;-.6,2.76,;.88,3.16,;1.28,4.65,)|
Structure:
Search PDB for entries with ligand similarity: