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Target
Tubulin polymerization-promoting protein
Ligand
BDBM59225
Substrate
n/a
Meas. Tech.
Cell Proliferation Assay
IC50
17±5 nM
Citation
 Kong, Y; Grembecka, J; Edler, MC; Hamel, E; Mooberry, SL; Sabat, M; Rieger, J; Brown, ML Structure-based discovery of a boronic acid bioisostere of combretastatin A-4. Chem Biol 12:1007-14 (2005) [PubMed]  Article 
Target
Name:
Tubulin polymerization-promoting protein
Synonyms:
TPPP | TPPP1 | TPPP_HUMAN | Tubulin | Tubulin polymerization-promoting protein
Type:
Protein
Mol. Mass.:
23706.03
Organism:
Homo sapiens (Human)
Description:
O94811
Residue:
219
Sequence:
MADKAKPAKAANRTPPKSPGDPSKDRAAKRLSLESEGAGEGAAASPELSALEEAFRRFAVHGDARATGREMHGKNWSKLCKDCQVIDGRNVTVTDVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGKAPIISGVTKAISSPTVSRLTDTTKFTGSHKERFDPSGKGKGKAGRVDLVDESGYVSGYKHAGTYDQKVQGGK
  
Inhibitor
Name:
BDBM59225
Synonyms:
Boronic acid, cis-6 | Boronic acid, trans-6
Type:
Small organic molecule
Emp. Form.:
C18H21BO6
Mol. Mass.:
344.167
SMILES:
COc1cc(C=Cc2ccc(OC)c(c2)B(O)O)cc(OC)c1OC |w:6.6|
Structure:
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