Reaction Details Report a problem with these data
Target
Ephrin type-A receptor 4 [1-949,A922V]
Ligand
BDBM82187
Substrate
n/a
Meas. Tech.
Enzyme-linked Immunosorbent Assay
pH
7.5±0
IC50
2.6e+3± 4e+2 nM
Citation
 Noberini, R; De, SK; Zhang, Z; Wu, B; Raveendra-Panickar, D; Chen, V; Vazquez, J; Qin, H; Song, J; Cosford, ND; Pellecchia, M; Pasquale, EB A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors. Chem Biol Drug Des 78:667-78 (2011) [PubMed]  Article 
Target
Name:
Ephrin type-A receptor 4 [1-949,A922V]
Synonyms:
EPHA4 | EPHA4_HUMAN | HEK8 | SEK | TYRO1
Type:
Protein
Mol. Mass.:
105739.43
Organism:
Homo sapiens (Human)
Description:
Q58F15
Residue:
949
Sequence:
MAGIFYFALFSCLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNCLCNAGHEERSGECQACKIGYYKALSTDATCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTKVSITDLLAHTNYTFEIWAVNGVSKYNPNPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESSRPNTALLDPSSPEFSAVVSVGDWLQVIKMDRYKDNFTAAGYTTLEAVVHVNQE
  
Inhibitor
Name:
BDBM82187
Synonyms:
Salicylic acid derivative, 76D10
Type:
Small organic molecule
Emp. Form.:
C27H18O9
Mol. Mass.:
486.4264
SMILES:
OC(=O)c1cc(ccc1O)-c1ccc(\C=C\C(=O)\C=C\c2ccc(o2)-c2ccc(O)c(c2)C(O)=O)o1
Structure:
Search PDB for entries with ligand similarity: