Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50240694
Substrate
n/a
Meas. Tech.
ChEMBL_1668532 (CHEMBL4018420)
EC50
>10000±n/a nM
Citation
 Davoren, JEGarnsey, MPettersen, BBrodney, MAEdgerton, JRFortin, JPGrimwood, SHarris, ARJenkinson, SKenakin, TLazzaro, JTLee, CWLotarski, SMNottebaum, LO'Neil, SVPopiolek, MRamsey, SSteyn, SJThorn, CAZhang, LWebb, D Design and Synthesis of?- and?-Lactam M J Med Chem 60:6649-6663 (2017) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50240694
Synonyms:
CHEMBL4067722
Type:
Small organic molecule
Emp. Form.:
C24H24N2O4
Mol. Mass.:
404.4584
SMILES:
Cc1cc2CN([C@H]3CCOC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-c1cocn1 |r|
Structure:
Search PDB for entries with ligand similarity: