Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50240692
Substrate
n/a
Meas. Tech.
ChEMBL_1668507 (CHEMBL4018395)
EC50
63±n/a nM
Citation
 Davoren, JE; Garnsey, M; Pettersen, B; Brodney, MA; Edgerton, JR; Fortin, JP; Grimwood, S; Harris, AR; Jenkinson, S; Kenakin, T; Lazzaro, JT; Lee, CW; Lotarski, SM; Nottebaum, L; O'Neil, SV; Popiolek, M; Ramsey, S; Steyn, SJ; Thorn, CA; Zhang, L; Webb, D Design and Synthesis of?- and?-Lactam M J Med Chem 60:6649-6663 (2017) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50240692
Synonyms:
CHEMBL4078588
Type:
Small organic molecule
Emp. Form.:
C25H25N3O2
Mol. Mass.:
399.4849
SMILES:
Cc1ccc(Cc2cc3c(ncn([C@H]4CCCC[C@@H]4O)c3=O)c3ccccc23)cn1 |r|
Structure:
Search PDB for entries with ligand similarity: