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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50258188
Substrate
n/a
Meas. Tech.
ChEMBL_1690275 (CHEMBL4040845)
Ki
2.7±n/a nM
Citation
 Fonseca, A; Reis, J; Silva, T; Matos, MJ; Bagetta, D; Ortuso, F; Alcaro, S; Uriarte, E; Borges, F Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis? J Med Chem 60:7206-7212 (2017) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50258188
Synonyms:
CHEMBL4060916
Type:
Small organic molecule
Emp. Form.:
C17H12ClNO3
Mol. Mass.:
313.735
SMILES:
Cc1ccc2occ(C(=O)Nc3cccc(Cl)c3)c(=O)c2c1
Structure:
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