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Target
Somatostatin receptor type 5
Ligand
BDBM50268215
Substrate
n/a
Meas. Tech.
ChEMBL_1704595 (CHEMBL4055828)
IC50
7.8±n/a nM
Citation
 Yamasaki, T; Hirose, H; Yamashita, T; Takakura, N; Morimoto, S; Nakahata, T; Kina, A; Nakano, Y; Okano Tamura, Y; Sugama, J; Odani, T; Shimizu, Y; Iwasaki, S; Watanabe, M; Maekawa, T; Kasai, S Discovery of novel somatostatin receptor subtype 5 (SSTR5) antagonists: Pharmacological studies and design to improve pharmacokinetic profiles and human Ether-a-go-go-related gene (hERG) inhibition. Bioorg Med Chem 25:4153-4162 (2017) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 5
Synonyms:
SS-5-R | SS5-R | SS5R | SSR5_MOUSE | Smstr5 | Somatostatin receptor | Somatostatin receptor 5 | Somatostatin receptor type 5 | Sstr5
Type:
PROTEIN
Mol. Mass.:
40022.97
Organism:
Mus musculus
Description:
ChEMBL_833921
Residue:
362
Sequence:
MEPLSLTSTPSWNASAASSSSHNWSLVDPVSPMGARAVLVPVLYLLVCTVGLGGNTLVIYVVLRYAKMKTVTNVYILNLAVADVLFMLGLPFLATQNAVSYWPFGSFLCRLVMTLDGINQFTSIFCLMVMSVDRYLAVVHPLRSARWRRPRVAKLASAAVWVFSLLMSLPLLVFADVQEGWGTCNLSWPEPVGLWGAAFITYTSVLGFFGPLLVICLCYLLIVVKVKAAGMRVGSSRRRRSERKVTRMVVVVVLVFVGCWLPFFIVNIVNLAFTLPEEPTSAGLYFFVVVLSYANSCANPLLYGFLSDNFRQSFRKALCLRRGYGVEDADAIEPRPDKSGRPQTTLPTRSCEANGLMQTSRL
  
Inhibitor
Name:
BDBM50268215
Synonyms:
CHEMBL4100114
Type:
Small organic molecule
Emp. Form.:
C30H36FN3O4
Mol. Mass.:
521.6229
SMILES:
CCOc1cc(CN2CC3(C2)CC(=NO3)N2CCC(C)(CC2)C(O)=O)cc(C2CC2)c1-c1ccc(F)cc1 |c:13|
Structure:
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