Reaction Details Report a problem with these data
Target
Nonstructural protein 5A
Ligand
BDBM50147212
Substrate
n/a
Meas. Tech.
ChEMBL_1711585 (CHEMBL4121634)
EC50
4.0±n/a nM
Citation
Nair, AG; Zeng, Q; Selyutin, O; Rosenblum, SB; Jiang, Y; Yang, DY; Keertikar, K; Zhou, G; Dwyer, M; Kim, SH; Shankar, B; Yu, W; Tong, L; Chen, L; Mazzola, R; Caldwell, J; Tang, H; Agrawal, S; Liu, R; Kong, R; Ingravallo, P; Xia, E; Zhai, Y; Nomeir, A; Asante-Appiah, E; Kozlowski, JA MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV. Bioorg Med Chem Lett 28:1954-1957 (2018) [PubMed] Article
More Info.:
Target
Name:
Nonstructural protein 5A
Synonyms:
NS5A | Nonstructural protein 5A
Type:
PROTEIN
Mol. Mass.:
48587.20
Organism:
Hepatitis C virus
Description:
ChEMBL_108438
Residue:
447
Sequence:
SGSWLRDVWDWICTVLTDFKTWLQSKLLPRIPGVPFLSCQRGYKGVWRGDGIMHTTCPCGAQITGHVKNGSMRIVGPKTCSNTWHGTFPINTYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFMVGLNQYLVGSQLPCEPEPDVTVLTSMLTDPSHITAETAGRRLARGSPPSLASSSASQLSAPSLKATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLQAEEDEREVSVPAEILRKSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLTESTVSSALAELATKTFGSSGSSAVDSGTATAPPDQLPGDGDSGSDVESYSSMPPLEGEPGDPDLSDGSWSTMSEEASEDVVCC