Reaction Details
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Amine oxidase [flavin-containing] A
Ligand
BDBM50283934
Substrate
n/a
Meas. Tech.
ChEMBL_1726367 (CHEMBL4141645)
IC50
380±n/a nM
Citation
Saddique, FA; Zaib, S; Jalil, S; Aslam, S; Ahmad, M; Sultan, S; Naz, H; Iqbal, M; Iqbal, J Synthesis, monoamine oxidase inhibition activity and molecular docking studies of novel 4-hydroxy-N'-[benzylidene or 1-phenylethylidene]-2-H/methyl/benzyl-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides. Eur J Med Chem 143:1373-1386 (2018) [PubMed] Article More Info.:
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_RAT | Amine oxidase (flavin-containing) A | Amine oxidase [flavin-containing] A | Maoa | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A (MAO-A) | Monoamine oxidase A (rMAO-A) | Monoamine oxidase type A (MAOA)
Type:
Enzyme
Mol. Mass.:
59515.21
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
526
Sequence:
MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC
Inhibitor
Name:
BDBM50283934
Synonyms:
CHEMBL4165825
Type:
Small organic molecule
Emp. Form.:
C15H17N3O4S
Mol. Mass.:
335.378
SMILES:
[#6]-[#7]1-[#6](-[#6](=O)-[#7]\[#7]=[#6]-2/[#6]-[#6]-[#6]-[#6]-2)=[#6](-[#8])-c2ccccc2S1(=O)=O |t:12|
Structure:
