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Target
Polyunsaturated fatty acid lipoxygenase ALOX15
Ligand
BDBM50015142
Substrate
n/a
Meas. Tech.
ChEBML_219
IC50
15000±n/a nM
Citation
 Huang, FC; Shoupe, TS; Lin, CJ; Lee, TD; Chan, WK; Tan, J; Schnapper, M; Suh, JT; Gordon, RJ; Sonnino, PA Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis. J Med Chem 32:1836-42 (1989) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX15
Synonyms:
12-LOX | 12/15-lipoxygenase | 15-LOX | Alox12l | Alox15 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, leukocyte-type | Arachidonate omega-6 lipoxygenase | LOX15_RAT
Type:
PROTEIN
Mol. Mass.:
75377.59
Organism:
Rattus norvegicus
Description:
ChEMBL_1510006
Residue:
663
Sequence:
MGVYRIRVSTGDSKYAGSNNEVYLWLVGQHGEASLGKLLRPCRDSEAEFKVDVSEYLGPLLFVRVQKWHYLTDDAWFCNWISVKGPGDQGSEYMFPCYRWVQGRSILSLPEGTGCTVVEDSQGLFRKHREEELEERRSLYRWGNWKDGSILNVAAASISDLPVDQRFREDKRIEFEASQVIGVMDTVVNFPINTVTCWKSLDDFNCVFKSGHTKMAERVRNSWKEDAFFGYQFLNGANPMVLKRSTCLPARLVFPPGMEKLQAQLNKELQKGTLFEADFFLLDGIKANVILCSQQYLAAPLVMLKLMPDGQLLPIAIQLELPKTGSTPPPIFTPSDPPMDWLLAKCWVRSSDLQLHELQAHLLRGHLMAEVFAVATMRCLPSVHPVFKLLVPHLLYTMEINVRARSDLISERGFFDKAMSTGGGGHLDLLKQAGAFLTYCSLCPPDDLAERGLLDIETCFYAKDALRLWQIMNRYVVGMFNLHYKTDKAVQDDYELQSWCREITDIGLQGAQDRGFPTSLQSRAQACYFITMCIFTCTAQHSSVHLGQLDWFYWVPNAPCTMRLPPPTTKEATMEKLMATLPNPNQSTLQINVVWLLGRRQAVMVPLGQHSEEHFPNPEAKAVLKKFREELAALDKEIEIRNKSLDIPYEYLRPSMVENSVAI
  
Inhibitor
Name:
BDBM50015142
Synonyms:
4-Phenylbutyrohydroxamic acid | CHEMBL55895 | N-Hydroxy-4-phenyl-butyramide
Type:
Small organic molecule
Emp. Form.:
C10H13NO2
Mol. Mass.:
179.2157
SMILES:
ONC(=O)CCCc1ccccc1
Structure:
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