Reaction Details Report a problem with these data
Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50017218
Substrate
n/a
Meas. Tech.
ChEMBL_100140 (CHEMBL712498)
IC50
>30000±n/a nM
Citation
 De, B; Plattner, JJ; Bush, EN; Jae, HS; Diaz, G; Johnson, ES; Perun, TJ LH-RH antagonists: design and synthesis of a novel series of peptidomimetics. J Med Chem 32:2036-8 (1989) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50017218
Synonyms:
2-sec-Butyl-4-[4-(4-{4-[2-(2,4-dichloro-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one | CHEMBL430787
Type:
Small organic molecule
Emp. Form.:
C36H39Cl2N7O4
Mol. Mass.:
704.645
SMILES:
CCC(C)n1ncn(-c2ccc(cc2)N2CCN(CC2)c2ccc(OC[C@H]3CO[C@@](Cn4ccnc4)(O3)c3ccc(Cl)cc3Cl)cc2)c1=O
Structure:
Search PDB for entries with ligand similarity: