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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50017221
Substrate
n/a
Meas. Tech.
ChEMBL_100140 (CHEMBL712498)
IC50
2000±n/a nM
Citation
 De, B; Plattner, JJ; Bush, EN; Jae, HS; Diaz, G; Johnson, ES; Perun, TJ LH-RH antagonists: design and synthesis of a novel series of peptidomimetics. J Med Chem 32:2036-8 (1989) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50017221
Synonyms:
2-[1-{[2-(2,4-Dichloro-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethyl]-carbamoyl}-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-5-oxo-pyrrolidine-1-carboxylic acid benzyl ester | CHEMBL3144570
Type:
Small organic molecule
Emp. Form.:
C33H33Cl2N7O7
Mol. Mass.:
710.564
SMILES:
Clc1ccc(c(Cl)c1)[C@@]1(Cn2ccnc2)OC[C@H](CNC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCC(=O)N2C(=O)OCc2ccccc2)O1
Structure:
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