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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50228320
Substrate
n/a
Meas. Tech.
ChEMBL_100140 (CHEMBL712498)
IC50
500±n/a nM
Citation
 De, B; Plattner, JJ; Bush, EN; Jae, HS; Diaz, G; Johnson, ES; Perun, TJ LH-RH antagonists: design and synthesis of a novel series of peptidomimetics. J Med Chem 32:2036-8 (1989) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50228320
Synonyms:
CHEMBL3144568
Type:
Small organic molecule
Emp. Form.:
C41H49Cl2N9O7
Mol. Mass.:
850.79
SMILES:
CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNCN1)C(=O)NC[C@H]1CO[C@@](Cn2ccnc2)(O1)c1ccc(Cl)cc1Cl |t:34|
Structure:
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