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Target
RNA-directed RNA polymerase
Ligand
BDBM50454923
Substrate
n/a
Meas. Tech.
ChEMBL_1753660 (CHEMBL4188420)
EC50
74±n/a nM
Citation
 Zhong, M; Peng, E; Huang, N; Huang, Q; Huq, A; Lau, M; Colonno, R; Li, L Discovery of novel potent HCV NS5B polymerase non-nucleoside inhibitors bearing a fused benzofuran scaffold. Bioorg Med Chem Lett 28:963-968 (2018) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50454923
Synonyms:
CHEMBL4218362
Type:
Small organic molecule
Emp. Form.:
C23H21FN4O4S
Mol. Mass.:
468.501
SMILES:
CNC(=O)c1c(oc2cc3N(Cc4nccn4C(C)c3cc12)S(C)(=O)=O)-c1ccc(F)cc1
Structure:
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