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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50460325
Substrate
n/a
Meas. Tech.
ChEMBL_1769288 (CHEMBL4221400)
EC50
48±n/a nM
Citation
 Matsuda, D; Kawamura, M; Kobashi, Y; Shiozawa, F; Suga, Y; Fusegi, K; Nishimoto, S; Kimura, K; Miyoshi, M; Takayama, N; Kakinuma, H; Ohtake, N Design, synthesis and biological evaluation of novel 7-azaspiro[3.5]nonane derivatives as GPR119 agonists. Bioorg Med Chem 26:1832-1847 (2018) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50460325
Synonyms:
CHEMBL4227435
Type:
Small organic molecule
Emp. Form.:
C24H34FN3O5
Mol. Mass.:
463.5423
SMILES:
CC(C)OC(=O)N1CCC2(CC(CCCOc3ccc(C(=O)NCC(N)=O)c(F)c3)C2)CC1
Structure:
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