Reaction Details Report a problem with these data
Target
P2Y purinoceptor 12
Ligand
BDBM50461335
Substrate
n/a
Meas. Tech.
ChEMBL_1771213 (CHEMBL4223325)
IC50
860±n/a nM
Citation
 Islam, I; Yuan, S; Wei, RG; Xu, W; Morrissey, M; Mohan, R; Zheng, D; DiMella, A; Dunning, L; Snider, M; Subramanyam, B; Tseng, JL; Bryant, JA; Buckman, BO Reversible, orally available ADP receptor (P2Y Bioorg Med Chem Lett 28:1459-1463 (2018) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 12
Synonyms:
ADP-glucose receptor | ADPG-R | HORK3 | P2RY12 | P2T(AC) | P2Y purinoceptor 12 | P2Y(AC) | P2Y(ADP) | P2Y(cyc) | P2Y12 | P2Y12 platelet ADP receptor | P2Y12_HUMAN | Purinergic receptor P2Y12 | SP1999
Type:
Enzyme
Mol. Mass.:
39458.48
Organism:
Homo sapiens (Human)
Description:
Q9H244
Residue:
342
Sequence:
MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
  
Inhibitor
Name:
BDBM50461335
Synonyms:
CHEMBL4229219
Type:
Small organic molecule
Emp. Form.:
C24H25N3O4
Mol. Mass.:
419.473
SMILES:
[#6]-[#6]-[#8]-[#6](=O)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](=O)-[#6]-[#7]-[#6](=O)\[#6]=[#6]-1/c2ccccc2-c2ccccc-12
Structure:
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