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Target
Transcriptional activator protein LasR
Ligand
BDBM50241433
Substrate
n/a
Meas. Tech.
ChEMBL_1788569 (CHEMBL4260303)
IC50
250±n/a nM
Citation
 Soukarieh, F; Williams, P; Stocks, MJ; Cámara, M Pseudomonas aeruginosa Quorum Sensing Systems as Drug Discovery Targets: Current Position and Future Perspectives. J Med Chem 61:10385-10402 (2018) [PubMed]  Article 
Target
Name:
Transcriptional activator protein LasR
Synonyms:
LASR_PSEAE | lasR
Type:
PROTEIN
Mol. Mass.:
26618.24
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_1475312
Residue:
239
Sequence:
MALVDGFLELERSSGKLEWSAILQKMASDLGFSKILFGLLPKDSQDYENAFIVGNYPAAWREHYDRAGYARVDPTVSHCTQSVLPIFWEPSIYQTRKQHEFFEEASAAGLVYGLTMPLHGARGELGALSLSVEAENRAEANRFMESVLPTLWMLKDYALQSGAGLAFEHPVSKPVVLTSREKEVLQWCAIGKTSWEISVICNCSEANVNFHMGNIRRKFGVTSRRVAAIMAVNLGLITL
  
Inhibitor
Name:
BDBM50241433
Synonyms:
(S)-3-(4-bromophenyl)-N-(2-oxo-tetrahydrofuran-3-yl)propanamide | (S)-3-(4-bromophenyl)-N-(2-oxotetrahydrofuran-3-yl)propanamide | CHEMBL264944
Type:
Small organic molecule
Emp. Form.:
C13H14BrNO3
Mol. Mass.:
312.159
SMILES:
Brc1ccc(CCC(=O)N[C@H]2CCOC2=O)cc1 |r|
Structure:
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