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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50474994
Substrate
n/a
Meas. Tech.
ChEMBL_312789 (CHEMBL833438)
IC50
0.300000±n/a nM
Citation
 Engler, TA; Malhotra, S; Burkholder, TP; Henry, JR; Mendel, D; Porter, WJ; Furness, K; Diefenbacher, C; Marquart, A; Reel, JK; Li, Y; Clayton, J; Cunningham, B; McLean, J; O'toole, JC; Brozinick, J; Hawkins, E; Misener, E; Briere, D; Brier, RA; Wagner, JR; Campbell, RM; Anderson, BD; Vaughn, R; Bennett, DB; Meier, TI; Cook, JA The development of potent and selective bisarylmaleimide GSK3 inhibitors. Bioorg Med Chem Lett 15:899-903 (2005) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM50474994
Synonyms:
Bisarylmaleimide 1
Type:
Small organic molecule
Emp. Form.:
C27H25N7O3
Mol. Mass.:
495.5325
SMILES:
O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4cccnn34)c3cccc(C1)c23 |t:15|
Structure:
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