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Target
Presenilin-1
Ligand
BDBM50476953
Substrate
n/a
Meas. Tech.
ChEMBL_447847 (CHEMBL898097)
IC50
14±n/a nM
Citation
 Parker, MF; Barten, DM; Bergstrom, CP; Bronson, JJ; Corsa, JA; Deshpande, MS; Felsenstein, KM; Guss, VL; Hansel, SB; Johnson, G; Keavy, DJ; Lau, WY; Mock, J; Prasad, CV; Polson, CT; Sloan, CP; Smith, DW; Wallace, OB; Wang, HH; Williams, A; Zheng, M N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors. Bioorg Med Chem Lett 17:4432-6 (2007) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50476953
Synonyms:
CHEMBL232949
Type:
Small organic molecule
Emp. Form.:
C20H23Cl2NO3S
Mol. Mass.:
428.373
SMILES:
CC(C1CCCC1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Structure:
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