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Target
Caspase-3
Ligand
BDBM50478883
Substrate
n/a
Meas. Tech.
ChEMBL_529187 (CHEMBL974963)
IC50
2350±n/a nM
Citation
 Gunasekera, SP; McCarthy, PJ; Longley, RE; Pomponi, SA; Wright, AE Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella. J Nat Prod 62:1208-11 (1999) [PubMed]  Article 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM50478883
Synonyms:
Secobatzelline A Diacetate
Type:
Small organic molecule
Emp. Form.:
C14H14ClN3O5
Mol. Mass.:
339.731
SMILES:
CC(=O)OCC(OC(C)=O)c1c[nH]c2c1C(=N)C(Cl)=C(N)C2=O |t:19|
Structure:
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