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Target
Protein kinase C zeta type
Ligand
BDBM50438882
Substrate
n/a
Meas. Tech.
ChEMBL_512034 (CHEMBL970837)
IC50
>345000±n/a nM
Citation
 Ali, HI; Tomita, K; Akaho, E; Kunishima, M; Kawashima, Y; Yamagishi, T; Ikeya, H; Nagamatsu, T Antitumor studies -- part 2: structure-activity relationship study for flavin analogs including investigations on their in vitro antitumor assay and docking simulation into protein tyrosine kinase. Eur J Med Chem 43:1376-89 (2008) [PubMed]  Article 
Target
Name:
Protein kinase C zeta type
Synonyms:
KPCZ_RAT | Pkcz | Prkcz | Protein kinase C (PKC) | Protein kinase C zeta type | nPKC-zeta
Type:
PROTEIN
Mol. Mass.:
67722.31
Organism:
Rattus norvegicus
Description:
ChEMBL_104731
Residue:
592
Sequence:
MPSRTDPKMDRSGGRVRLKAHYGGDILITSVDPTTTFQDLCEEVRDMCGLHQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLACQGRDEVLIIHVFPSIPEQPGMPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHVLVPLTCRRHMDSVMPSQEPPVDDKNDGVDLPSEETDGIAYISSSRKHDNIKDDSEDLKPVIDGVDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQTLPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDVIKRIDQSEFEGFEYINPLLLSAEESV
  
Inhibitor
Name:
BDBM50438882
Synonyms:
10-Phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (5) | CHEMBL471342
Type:
Small organic molecule
Emp. Form.:
C17H11N3O2
Mol. Mass.:
289.2881
SMILES:
O=c1nc2n(-c3ccccc3)c3ccccc3cc2c(=O)[nH]1
Structure:
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