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Found 306 with Last Name = 'yamagishi' and Initial = 't'
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262566((2S,3S)-3-[(1R)-6-Methoxy-1-methyl-1-trifluorometh...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50232544(CHEMBL4099851)
Affinity DataKi:  0.970nMAssay Description:Antagonist activity at human EP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Askat

Curated by ChEMBL
LigandPNGBDBM50232544(CHEMBL4099851)
Affinity DataKi:  6.10nMAssay Description:Antagonist activity at rat recombinant EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50107283(AAT-007 | CJ-023 | Grapiprant | MR-10A7 | RQ-00000...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]PGE from human EP4 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50067935((2-Methoxy-5-trifluoromethoxy-benzyl)-((2S,3S)-2-p...)
Affinity DataKi:  20nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Askat

Curated by ChEMBL
LigandPNGBDBM50107283(AAT-007 | CJ-023 | Grapiprant | MR-10A7 | RQ-00000...)
Affinity DataKi:  20nMAssay Description:Antagonist activity at rat recombinant EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262395(CHEMBL478620 | R/S-(2S,3S)-N-((6-methoxy-3-(triflu...)
Affinity DataKi:  20nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Canis lupus familiaris)
Askat

Curated by ChEMBL
LigandPNGBDBM50107283(AAT-007 | CJ-023 | Grapiprant | MR-10A7 | RQ-00000...)
Affinity DataKi:  24nMAssay Description:Antagonist activity at dog recombinant EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Canis lupus familiaris)
Askat

Curated by ChEMBL
LigandPNGBDBM50232544(CHEMBL4099851)
Affinity DataKi:  38nMAssay Description:Antagonist activity at dog recombinant EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262280(CHEMBL513351 | R/S-(2S,3S)-N-(2-methoxy-5-(1,1,1-t...)
Affinity DataKi:  70nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50232546(CHEMBL4103046)
Affinity DataKi:  73nMAssay Description:Displacement of [3H]PGE from human EP4 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262510(CHEMBL477365 | R/S-(2S,3S)-3-[((6-Methoxy-1-methyl...)
Affinity DataKi:  120nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrehalase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286541(6-(4,5-Dihydroxy-6-hydroxymethyl-tetrahydro-pyran-...)
Affinity DataKi:  180nMAssay Description:Evaluated for the inhibition of trehalase from porcine kidneysMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262567(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  420nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262279((2S,3S)-N-((6-methoxy-3-methyl-3-(trifluoromethyl)...)
Affinity DataKi:  660nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224198((2S,3S)-N-(2-methoxy-5-(1,1,1-trifluoro-2-methylpr...)
Affinity DataKi:  840nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50232544(CHEMBL4099851)
Affinity DataKi:  1.84E+3nMAssay Description:Antagonist activity at human EP2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262337((2S,3S)-N-(5-(1,1,1,3,3,3-hexafluoropropan-2-yl)-2...)
Affinity DataKi:  2.10E+3nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262281((2S,3S)-3-[2-Methoxy-5-(2,2,2-trifluoroethyl)benzy...)
Affinity DataKi:  4.25E+3nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50107283(AAT-007 | CJ-023 | Grapiprant | MR-10A7 | RQ-00000...)
Affinity DataKi: >5.00E+3nMAssay Description:Antagonist activity at human EP1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50107283(AAT-007 | CJ-023 | Grapiprant | MR-10A7 | RQ-00000...)
Affinity DataKi: >5.00E+3nMAssay Description:Antagonist activity at human platelet TP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50107283(AAT-007 | CJ-023 | Grapiprant | MR-10A7 | RQ-00000...)
Affinity DataKi: >5.00E+3nMAssay Description:Antagonist activity at human FP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50107283(AAT-007 | CJ-023 | Grapiprant | MR-10A7 | RQ-00000...)
Affinity DataKi: >5.00E+3nMAssay Description:Antagonist activity at human IP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50107283(AAT-007 | CJ-023 | Grapiprant | MR-10A7 | RQ-00000...)
Affinity DataKi: >5.00E+3nMAssay Description:Antagonist activity at human EP2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50107283(AAT-007 | CJ-023 | Grapiprant | MR-10A7 | RQ-00000...)
Affinity DataKi: >5.00E+3nMAssay Description:Antagonist activity at human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50232544(CHEMBL4099851)
Affinity DataKi: >6.00E+3nMAssay Description:Displacement of [3H]PGE from human EP4 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50232544(CHEMBL4099851)
Affinity DataKi: >6.00E+3nMAssay Description:Antagonist activity at human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50232544(CHEMBL4099851)
Affinity DataKi: >6.00E+3nMAssay Description:Antagonist activity at human platelet TP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50232544(CHEMBL4099851)
Affinity DataKi: >6.00E+3nMAssay Description:Antagonist activity at human FP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50232544(CHEMBL4099851)
Affinity DataKi: >6.00E+3nMAssay Description:Antagonist activity at human IP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262279((2S,3S)-N-((6-methoxy-3-methyl-3-(trifluoromethyl)...)
Affinity DataIC50:  0.160nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224198((2S,3S)-N-(2-methoxy-5-(1,1,1-trifluoro-2-methylpr...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50261732((2S,3S)-N-(((S)-6-methoxy-1-methyl-1-(trifluoromet...)
Affinity DataIC50:  0.340nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262510(CHEMBL477365 | R/S-(2S,3S)-3-[((6-Methoxy-1-methyl...)
Affinity DataIC50:  0.340nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262510(CHEMBL477365 | R/S-(2S,3S)-3-[((6-Methoxy-1-methyl...)
Affinity DataIC50:  0.340nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50067935((2-Methoxy-5-trifluoromethoxy-benzyl)-((2S,3S)-2-p...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262280(CHEMBL513351 | R/S-(2S,3S)-N-(2-methoxy-5-(1,1,1-t...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262453(CHEMBL479049 | R/S-(2S,3S)-N-((3-methoxy-8-(triflu...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262336(CHEMBL468163 | R/S-(2S,3S)-N-(2-methoxy-5-(1,2,2,2...)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262395(CHEMBL478620 | R/S-(2S,3S)-N-((6-methoxy-3-(triflu...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262395(CHEMBL478620 | R/S-(2S,3S)-N-((6-methoxy-3-(triflu...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262281((2S,3S)-3-[2-Methoxy-5-(2,2,2-trifluoroethyl)benzy...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262394(CHEMBL515935 | R/S-(2S,3S)-N-(2-methoxy-5-(1,1,1-t...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50232544(CHEMBL4099851)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [3H]PGE from human EP4 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50232550(CHEMBL4062620)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]PGE from human EP4 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50355882(CHEMBL591666)
Affinity DataIC50:  6.60nMAssay Description:Displacement of [3H]PGE from human EP4 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50232545(CHEMBL4078648)
Affinity DataIC50:  8.80nMAssay Description:Displacement of [3H]PGE from human EP4 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50232543(CHEMBL4096216)
Affinity DataIC50:  9.70nMAssay Description:Displacement of [3H]PGE from human EP4 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50232548(CHEMBL4094572)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]PGE from human EP4 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Askat

Curated by ChEMBL
LigandPNGBDBM50232544(CHEMBL4099851)
Affinity DataIC50:  16nMAssay Description:Displacement of [3H]PGE from human EP4 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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