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Target
3-oxoacyl-[acyl-carrier-protein] synthase 2
Ligand
BDBM50479865
Substrate
n/a
Meas. Tech.
ChEMBL_566016 (CHEMBL964115)
IC50
1130±n/a nM
Citation
 Shen, HC; Ding, FX; Singh, SB; Parthasarathy, G; Soisson, SM; Ha, SN; Chen, X; Kodali, S; Wang, J; Dorso, K; Tata, JR; Hammond, ML; Maccoss, M; Colletti, SL Synthesis and biological evaluation of platensimycin analogs. Bioorg Med Chem Lett 19:1623-7 (2009) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 2
Synonyms:
2.3.1.179 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 3-oxoacyl-[acyl-carrier-protein] synthase II | Beta-ketoacyl-ACP synthase II | FABF_STAAU | KAS II | fabF
Type:
PROTEIN
Mol. Mass.:
42419.21
Organism:
Staphylococcus aureus
Description:
ChEMBL_100958
Residue:
403
Sequence:
VITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNIEDHIDKKEARRMDRFTQYAIVAAREAVKDAQLDINENTADRIGVWIGSGIGGMETFEIAHKQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQRGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILVIESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQYLNAHGTSTPVGDLNEVKAIKNTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKDSKIAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFK
  
Inhibitor
Name:
BDBM50479865
Synonyms:
Platensimycin
Type:
Small organic molecule
Emp. Form.:
C24H27NO7
Mol. Mass.:
441.4737
SMILES:
[H][C@@]12CC3C[C@]4(CC3(C)O1)C=CC(=O)[C@@](C)(CCC(=O)Nc1c(O)ccc(C(O)=O)c1O)C24 |r,c:12,TLB:14:32:2:9.7,THB:6:5:2:9.7,6:7:2:5.4.32,8:7:2:5.4.32|
Structure:
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