Reaction Details Report a problem with these data
Target
3-oxoacyl-[acyl-carrier-protein] synthase 2
Ligand
BDBM50479874
Substrate
n/a
Meas. Tech.
ChEMBL_566016 (CHEMBL964115)
IC50
>436000±n/a nM
Citation
 Shen, HC; Ding, FX; Singh, SB; Parthasarathy, G; Soisson, SM; Ha, SN; Chen, X; Kodali, S; Wang, J; Dorso, K; Tata, JR; Hammond, ML; Maccoss, M; Colletti, SL Synthesis and biological evaluation of platensimycin analogs. Bioorg Med Chem Lett 19:1623-7 (2009) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 2
Synonyms:
2.3.1.179 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 3-oxoacyl-[acyl-carrier-protein] synthase II | Beta-ketoacyl-ACP synthase II | FABF_STAAU | KAS II | fabF
Type:
PROTEIN
Mol. Mass.:
42419.21
Organism:
Staphylococcus aureus
Description:
ChEMBL_100958
Residue:
403
Sequence:
VITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNIEDHIDKKEARRMDRFTQYAIVAAREAVKDAQLDINENTADRIGVWIGSGIGGMETFEIAHKQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQRGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILVIESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQYLNAHGTSTPVGDLNEVKAIKNTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKDSKIAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFK
  
Inhibitor
Name:
BDBM50479874
Synonyms:
CHEMBL492364
Type:
Small organic molecule
Emp. Form.:
C24H30N2O7
Mol. Mass.:
458.5042
SMILES:
CN1CC23CC4CC(OC4(C)C2)C3[C@](C)(CCC(=O)Nc2c(O)ccc(C(O)=O)c2O)C1=O |r,TLB:13:12:11:5.4,6:7:11:5.4,THB:6:5:12.7.8:11|
Structure:
Search PDB for entries with ligand similarity: