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Target
Reverse transcriptase
Ligand
BDBM50480625
Substrate
n/a
Meas. Tech.
ChEMBL_579309 (CHEMBL1054760)
IC50
114±n/a nM
Citation
 Buckheit, RW; Hartman, TL; Watson, KM; Chung, SG; Cho, EH Comparative evaluation of the inhibitory activities of a series of pyrimidinedione congeners that inhibit human immunodeficiency virus types 1 and 2. Antimicrob Agents Chemother 52:225-36 (2008) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50480625
Synonyms:
CHEMBL562570
Type:
Small organic molecule
Emp. Form.:
C22H24N2O3
Mol. Mass.:
364.4376
SMILES:
CC(C)c1c(Oc2cc(C)cc(C)c2)n(Cc2ccccc2)c(=O)[nH]c1=O
Structure:
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