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Target
3-oxoacyl-[acyl-carrier-protein] synthase 2
Ligand
BDBM50483833
Substrate
n/a
Meas. Tech.
ChEMBL_745353 (CHEMBL1775473)
IC50
2850±n/a nM
Citation
 Zhang, C; Ondeyka, J; Herath, K; Jayasuriya, H; Guan, Z; Zink, DL; Dietrich, L; Burgess, B; Ha, SN; Wang, J; Singh, SB Platensimycin and platencin congeners from Streptomyces platensis. J Nat Prod 74:329-40 (2011) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 2
Synonyms:
2.3.1.179 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 3-oxoacyl-[acyl-carrier-protein] synthase II | Beta-ketoacyl-ACP synthase II | FABF_STAAU | KAS II | fabF
Type:
PROTEIN
Mol. Mass.:
42419.21
Organism:
Staphylococcus aureus
Description:
ChEMBL_100958
Residue:
403
Sequence:
VITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNIEDHIDKKEARRMDRFTQYAIVAAREAVKDAQLDINENTADRIGVWIGSGIGGMETFEIAHKQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQRGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILVIESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQYLNAHGTSTPVGDLNEVKAIKNTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKDSKIAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFK
  
Inhibitor
Name:
BDBM50483833
Synonyms:
Platensimycin A1
Type:
Small organic molecule
Emp. Form.:
C24H25NO8
Mol. Mass.:
455.4572
SMILES:
[H][C@]12[C@]34C[C@]33C[C@@]1(C=CC(=O)[C@@]2(C)CCC(=O)Nc1c(O)ccc(C(O)=O)c1O)[C@@H](O)[C@]3(C)O4 |r,c:9,TLB:32:31:1.2:5,3:2:5:29.31,33:2:5:29.31,THB:30:29:1.2:5,11:1:5:29.31,33:31:1.2:5|
Structure:
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