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Target
Tubulin beta chain
Ligand
BDBM50484509
Substrate
n/a
Meas. Tech.
ChEMBL_792480 (CHEMBL1929810)
IC50
>20000±n/a nM
Citation
 Akselsen, OW; Odlo, K; Cheng, JJ; Maccari, G; Botta, M; Hansen, TV Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1. Bioorg Med Chem 20:234-42 (2012) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50484509
Synonyms:
CHEMBL1927603
Type:
Small organic molecule
Emp. Form.:
C18H17N5O8
Mol. Mass.:
431.3563
SMILES:
COc1ccc(-c2cnnn2-c2cc(OC)c(OC)c(OC)c2)c(c1[N+]([O-])=O)[N+]([O-])=O
Structure:
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