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Target
Mitogen-activated protein kinase 11
Ligand
BDBM50492386
Substrate
n/a
Meas. Tech.
ChEMBL_972017 (CHEMBL2405968)
Kd
6.2±n/a nM
Citation
 Wrobleski, ST; Lin, S; Dhar, TG; Dyckman, AJ; Li, T; Pitt, S; Zhang, R; Fan, Y; Doweyko, AM; Tokarski, JS; Kish, KF; Kiefer, SE; Sack, JS; Newitt, JA; Witmer, MR; McKinnon, M; Barrish, JC; Dodd, JH; Schieven, GL; Leftheris, K The identification of novel p38? isoform selective kinase inhibitors having an unprecedented p38? binding mode. Bioorg Med Chem Lett 23:4120-6 (2013) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 11
Synonyms:
MAP kinase p38 | MAPK11 | MK11_HUMAN | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | PRKM11 | SAPK2 | SAPK2B | Stress-activated protein kinase 2 | p38 MAP kinase alpha/beta | p38-2 | p38-beta | p38b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41351.73
Organism:
Homo sapiens (Human)
Description:
gi_20128774
Residue:
364
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIEQ
  
Inhibitor
Name:
BDBM50492386
Synonyms:
CHEMBL2401979
Type:
Small organic molecule
Emp. Form.:
C22H20F3N5O2
Mol. Mass.:
443.4217
SMILES:
Cc1c(cnn1-c1ncccc1C(F)(F)F)C(=O)Nc1cc(ccc1C)C(=O)NC1CC1
Structure:
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