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Found 1576 with Last Name = 'wrobleski' and Initial = 'st'
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50507816(Bms-986165 | Deucravacitinib)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of fluorescein labeled probe binding to His-tagged human TYK2 pseudokinase domain (575-869 residues) by Morrison titration based HTRF assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16318(3-({5-cyano-6-[(2,2-dimethylpropyl)(methyl)amino]-...)
Affinity DataKi:  0.0470nM ΔG°:  -58.4kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16319(3-({2-amino-5-cyano-6-[(2,2-dimethylpropyl)(methyl...)
Affinity DataKi:  0.0500nM ΔG°:  -58.2kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16317(3-({5-cyano-6-[(2,2-dimethylpropyl)(methyl)amino]-...)
Affinity DataKi:  0.0570nM ΔG°:  -57.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16329(3-({2-amino-5-cyano-6-[(1-methylethyl)amino]pyrimi...)
Affinity DataKi:  0.0570nM ΔG°:  -57.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of TYK2 JH2 (unknown origin) by morrison titration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of TYK2 JH2 (unknown origin) by morrison titration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50519523(CHEMBL4440718)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of TYK2 JH2 (unknown origin) by morrison titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50519523(CHEMBL4440718)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of TYK2 JH2 (unknown origin) by morrison titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16320(3-({5-cyano-6-[(2,2-dimethylpropyl)(methyl)amino]p...)
Affinity DataKi:  0.150nM ΔG°:  -55.5kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16330(3-{[2-amino-5-cyano-6-(cyclopentylamino)pyrimidin-...)
Affinity DataKi:  0.160nM ΔG°:  -55.3kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity of compound was determined against to human cannabinoid receptor 2 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16325(3-({5-cyano-6-[(1-methylethyl)amino]pyrimidin-4-yl...)
Affinity DataKi:  0.410nM ΔG°:  -53.0kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50376456(CHEMBL262592)
Affinity DataKi:  0.420nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16324(3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]ami...)
Affinity DataKi:  0.420nM ΔG°:  -53.0kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50376433(CHEMBL258895)
Affinity DataKi:  0.440nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50376434(CHEMBL408150)
Affinity DataKi:  0.460nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50376435(CHEMBL261845)
Affinity DataKi:  0.540nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16323(3-({5-cyano-6-[(1-methylethyl)amino]pyrimidin-4-yl...)
Affinity DataKi:  0.610nM ΔG°:  -52.1kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50530395(CHEMBL4444178)
Affinity DataKi:  0.800nMAssay Description:Inhibition of TYK2 JH2 (unknown origin) by morrison titration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50530395(CHEMBL4444178)
Affinity DataKi:  0.800nMAssay Description:Inhibition of TYK2 JH2 (unknown origin) by morrison titration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16322(3-{[5-cyano-6-(propylamino)pyrimidin-4-yl]amino}-N...)
Affinity DataKi:  0.970nM ΔG°:  -50.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50376432(CHEMBL258748)
Affinity DataKi:  0.980nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50272598(6-Methoxy-5-(2-morpholin-4-yl-ethyl)-2-(1,3,3-trim...)
Affinity DataKi:  1nMAssay Description:Binding affinity against human cannabinoid receptor 2 in chinese hamster ovary cells using WIN-55212-2 mesylate[57-3H]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16331(3-({2-amino-5-cyano-6-[(1-methylethyl)amino]pyrimi...)
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16326(3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]ami...)
Affinity DataKi:  1.60nM ΔG°:  -49.7kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16332(3-{[2-amino-5-cyano-6-(cyclopentylamino)pyrimidin-...)
Affinity DataKi:  1.90nM ΔG°:  -49.3kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity of compound was determined against to human cannabinoid receptor 1 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50128092(7-Methoxy-1-(2-morpholin-4-yl-ethyl)-1H-indazole-3...)
Affinity DataKi:  2nMAssay Description:Binding affinity against human cannabinoid receptor 2 in chinese hamster ovary cells using WIN-55212-2 mesylate[57-3H]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM50376457(CHEMBL259596)
Affinity DataKi:  3.40nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataKi:  3.70nM ΔG°:  -47.6kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50128095(7-Methoxy-2-methyl-1-(2-morpholin-4-yl-ethyl)-1H-i...)
Affinity DataKi:  8nMAssay Description:Binding affinity of compound against human cannabinoid receptor 1 in chinese hamster ovary cells by using radioligand CP-55940More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50128100(7-Methoxy-1-(2-morpholin-4-yl-ethyl)-1H-indole-3-c...)
Affinity DataKi:  11nMAssay Description:Binding affinity against human cannabinoid receptor 2 in chinese hamster ovary cells using WIN-55212-2 mesylate[57-3H]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16328(3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]ami...)
Affinity DataKi:  14nM ΔG°:  -44.4kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16327(3-({5-cyano-6-[(1-methylethyl)amino]pyrimidin-4-yl...)
Affinity DataKi:  15nM ΔG°:  -44.2kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16321(3-{[5-cyano-6-(methylamino)pyrimidin-4-yl]amino}-N...)
Affinity DataKi:  16nM ΔG°:  -44.0kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50272598(6-Methoxy-5-(2-morpholin-4-yl-ethyl)-2-(1,3,3-trim...)
Affinity DataKi:  16nMAssay Description:Binding affinity of compound against human cannabinoid receptor 1 in chinese hamster ovary cells by using radioligand CP-55940More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50128092(7-Methoxy-1-(2-morpholin-4-yl-ethyl)-1H-indazole-3...)
Affinity DataKi:  24nMAssay Description:Binding affinity of compound against human cannabinoid receptor 1 in chinese hamster ovary cells by using radioligand CP-55940More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50128095(7-Methoxy-2-methyl-1-(2-morpholin-4-yl-ethyl)-1H-i...)
Affinity DataKi:  29nMAssay Description:Binding affinity against human cannabinoid receptor 2 in chinese hamster ovary cells using WIN-55212-2 mesylate[57-3H]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50128094(6-Methoxy-2-(2-methoxy-benzyl)-5-(2-morpholin-4-yl...)
Affinity DataKi:  67nMAssay Description:Binding affinity against human cannabinoid receptor 2 in chinese hamster ovary cells using WIN-55212-2 mesylate[57-3H]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50128096(7-Methoxy-1-(2-morpholin-4-yl-ethyl)-1H-indazole-3...)
Affinity DataKi:  69nMAssay Description:Binding affinity against human cannabinoid receptor 2 in chinese hamster ovary cells using WIN-55212-2 mesylate[57-3H]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50128097(7-Methoxy-1-(2-morpholin-4-yl-ethyl)-1H-indazole-3...)
Affinity DataKi:  77nMAssay Description:Binding affinity against human cannabinoid receptor 2 in chinese hamster ovary cells using WIN-55212-2 mesylate[57-3H]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50128098(2-Ethyl-7-methoxy-1-(2-morpholin-4-yl-ethyl)-1H-in...)
Affinity DataKi:  110nMAssay Description:Binding affinity against human cannabinoid receptor 2 in chinese hamster ovary cells using WIN-55212-2 mesylate[57-3H]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50128093(7-Methoxy-1-(2-morpholin-4-yl-ethyl)-1H-indazole-3...)
Affinity DataKi:  146nMAssay Description:Binding affinity against human cannabinoid receptor 2 in chinese hamster ovary cells using WIN-55212-2 mesylate[57-3H]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50128093(7-Methoxy-1-(2-morpholin-4-yl-ethyl)-1H-indazole-3...)
Affinity DataKi:  162nMAssay Description:Binding affinity of compound against human cannabinoid receptor 1 in chinese hamster ovary cells by using radioligand CP-55940More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50128100(7-Methoxy-1-(2-morpholin-4-yl-ethyl)-1H-indole-3-c...)
Affinity DataKi:  245nMAssay Description:Binding affinity of compound against human cannabinoid receptor 1 in chinese hamster ovary cells by using radioligand CP-55940More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50128094(6-Methoxy-2-(2-methoxy-benzyl)-5-(2-morpholin-4-yl...)
Affinity DataKi:  3.70E+3nMAssay Description:Binding affinity of compound against human cannabinoid receptor 1 in chinese hamster ovary cells by using radioligand CP-55940More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM141485(US8921368, 293)
Affinity DataIC50:  0.100nMpH: 7.4 T: 2°CAssay Description:The assay reactions were performed in U-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme and substr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM151084(US8987268, 183)
Affinity DataIC50:  0.200nMpH: 7.4 T: 2°CAssay Description:The assay reactions were performed in U-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme and substrat...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM151051(US8987268, 105)
Affinity DataIC50:  0.200nMpH: 7.4 T: 2°CAssay Description:The assay reactions were performed in U-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme and substrat...More data for this Ligand-Target Pair
In DepthDetails US Patent
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