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Target
3',5'-cyclic-AMP phosphodiesterase
Ligand
BDBM50041880
Substrate
n/a
Meas. Tech.
ChEMBL_157209 (CHEMBL768860)
IC50
400±n/a nM
Citation
 Ashton, MJ; Cook, DC; Fenton, G; Karlsson, JA; Palfreyman, MN; Raeburn, D; Ratcliffe, AJ; Souness, JE; Thurairatnam, S; Vicker, N Selective type IV phosphodiesterase inhibitors as antiasthmatic agents. The syntheses and biological activities of 3-(cyclopentyloxy)-4-methoxybenzamides and analogues. J Med Chem 37:1696-703 (1994) [PubMed]  Article 
Target
Name:
3',5'-cyclic-AMP phosphodiesterase
Synonyms:
Phosphodiesterase 4A
Type:
PROTEIN
Mol. Mass.:
13615.65
Organism:
Sus scrofa
Description:
ChEMBL_155848
Residue:
118
Sequence:
PWLVGWWDQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVDIPSPTMKDHEKQQAPRQRPSQQPPPPGPQFQPMSQITGVKKLMHSSSLNEDSSIPRFGVKTDQEELLAQEL
  
Inhibitor
Name:
BDBM50041880
Synonyms:
3-Cyclopentyloxy-N-(2,6-dichloro-6H-pyrimidin-1-yl)-4-methoxy-benzamide | CHEMBL298792
Type:
Small organic molecule
Emp. Form.:
C17H19Cl2N3O3
Mol. Mass.:
384.257
SMILES:
COc1ccc(cc1OC1CCCC1)C(=O)NN1C(Cl)C=CN=C1Cl |c:22,24|
Structure:
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