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Target
Integrase
Ligand
BDBM50496319
Substrate
n/a
Meas. Tech.
ChEMBL_1297949 (CHEMBL3132334)
IC50
27±n/a nM
Citation
 Zhao, XZ; Smith, SJ; Métifiot, M; Johnson, BC; Marchand, C; Pommier, Y; Hughes, SH; Burke, TR Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants. J Med Chem 57:1573-82 (2014) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50496319
Synonyms:
CHEMBL3125970
Type:
Small organic molecule
Emp. Form.:
C16H11ClFN3O4
Mol. Mass.:
363.728
SMILES:
Oc1c(C(=O)NCc2ccc(F)c(Cl)c2)c(=O)n(O)c2ncccc12
Structure:
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