Reaction Details Report a problem with these data
Target
Friend leukemia integration 1 transcription factor
Ligand
BDBM50497661
Substrate
n/a
Meas. Tech.
ChEMBL_1440215 (CHEMBL3383760)
Kd
4800±n/a nM
Citation
 Tosso, PN; Kong, Y; Scher, L; Cummins, R; Schneider, J; Rahim, S; Holman, KT; Toretsky, J; Wang, K; Üren, A; Brown, ML Synthesis and structure-activity relationship studies of small molecule disruptors of EWS-FLI1 interactions in Ewing's sarcoma. J Med Chem 57:10290-303 (2014) [PubMed]  Article 
Target
Name:
Friend leukemia integration 1 transcription factor
Synonyms:
FLI1 | FLI1_HUMAN | Friend leukemia integration 1 transcription factor | Proto-oncogene Fli-1 | Transcription factor ERGB
Type:
PROTEIN
Mol. Mass.:
50985.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117112
Residue:
452
Sequence:
MDGTIKEALSVVSDDQSLFDSAYGAAAHLPKADMTASGSPDYGQPHKINPLPPQQEWINQPVRVNVKREYDHMNGSRESPVDCSVSKCSKLVGGGESNPMNYNSYMDEKNGPPPPNMTTNERRVIVPADPTLWTQEHVRQWLEWAIKEYSLMEIDTSFFQNMDGKELCKMNKEDFLRATTLYNTEVLLSHLSYLRESSLLAYNTTSHTDQSSRLSVKEDPSYDSVRRGAWGNNMNSGLNKSPPLGGAQTISKNTEQRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPTESSMYKYPSDISYMPSYHAHQQKVNFVPPHPSSMPVTSSSFFGAASQYWTSPTGGIYPNPNVPRHPNTHVPSHLGSYY
  
Inhibitor
Name:
BDBM50497661
Synonyms:
CHEMBL3360410
Type:
Small organic molecule
Emp. Form.:
C33H39Cl2N5O6S
Mol. Mass.:
704.664
SMILES:
CN(C(=O)CCCCCNC(=O)CCCC[C@H]1SCC2NC(=O)NC12)c1ccc(cc1)C(=O)CC1(O)C(=O)Nc2c1c(Cl)ccc2Cl |r|
Structure:
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