Reaction Details Report a problem with these data
Target
Neuromedin-U receptor 1
Ligand
BDBM50500786
Substrate
n/a
Meas. Tech.
ChEMBL_1550246 (CHEMBL3760529)
EC50
6310±n/a nM
Citation
 Micewicz, ED; Bahattab, OS; Willars, GB; Waring, AJ; Navab, M; Whitelegge, JP; McBride, WH; Ruchala, P Small lipidated anti-obesity compounds derived from neuromedin U. Eur J Med Chem 101:616-26 (2015) [PubMed]  Article 
Target
Name:
Neuromedin-U receptor 1
Synonyms:
G-protein coupled receptor 66 | G-protein coupled receptor FM-3 | GPR66 | NMU-R1 | NMUR1 | NMUR1_HUMAN | Neuromedin-U receptor 1
Type:
PROTEIN
Mol. Mass.:
47370.42
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103121
Residue:
426
Sequence:
MTPLCLNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWHNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMSSRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQQETDPS
  
Inhibitor
Name:
BDBM50500786
Synonyms:
CHEMBL4299255
Type:
Small organic molecule
Emp. Form.:
C92H147N19O12S3
Mol. Mass.:
1807.467
SMILES:
[H][C@]12C[C@]3([H])N(C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc4ccccc4)NC(=O)CCCCCNC(=O)[C@H](N)CSCc4cc(CSCCCCCCCCCCCCCCCC)cc(CSC[C@@H](NC(=O)CCCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC3=O)C(N)=O)c4)[C@@]1([H])CCCC2 |r|
Structure:
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