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Target
TGF-beta receptor type-1
Ligand
BDBM50504975
Substrate
n/a
Meas. Tech.
ChEMBL_1816948 (CHEMBL4316522)
IC50
790±n/a nM
Citation
 Haffner, CD; Charnley, AK; Aquino, CJ; Casillas, L; Convery, MA; Cox, JA; Elban, MA; Goodwin, NC; Gough, PJ; Haile, PA; Hughes, TV; Knapp-Reed, B; Kreatsoulas, C; Lakdawala, AS; Li, H; Lian, Y; Lipshutz, D; Mehlmann, JF; Ouellette, M; Romano, J; Shewchuk, L; Shu, A; Votta, BJ; Zhou, H; Bertin, J; Marquis, RW Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors. ACS Med Chem Lett 10:1518-1523 (2019) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50504975
Synonyms:
CHEMBL4475515
Type:
Small organic molecule
Emp. Form.:
C14H15N5OS
Mol. Mass.:
301.367
SMILES:
CCn1nc(c(C(N)=O)c1NC)-c1ccc2scnc2c1
Structure:
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