Compile Data Set for Download or QSAR
maximum 50k data
Found 2196 with Last Name = 'shewchuk' and Initial = 'l'
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167296((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-ethylhyd...)
Affinity DataKi:  0.00300nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167295((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-propylhy...)
Affinity DataKi:  0.00400nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167302((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-isobutyl...)
Affinity DataKi:  0.00400nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167298((1S)-2-cyclohexyl-1-methylethyl 2-benzyl-2-cyanohy...)
Affinity DataKi:  0.00600nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167303((1S)-2-cyclohexyl-1-methylethyl 2-butyl-2-cyanohyd...)
Affinity DataKi:  0.00700nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167289((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-methylhy...)
Affinity DataKi:  0.00900nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167290((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-isopropy...)
Affinity DataKi:  0.0190nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167289((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-methylhy...)
Affinity DataKi:  0.0250nMAssay Description:Inhibition constant against human cathepsin L using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167288((1S)-1-benzylpropyl 2-cyano-2-methylhydrazinecarbo...)
Affinity DataKi:  0.0320nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167288((1S)-1-benzylpropyl 2-cyano-2-methylhydrazinecarbo...)
Affinity DataKi:  0.0360nMAssay Description:Inhibition constant against human cathepsin L using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167288((1S)-1-benzylpropyl 2-cyano-2-methylhydrazinecarbo...)
Affinity DataKi:  0.0720nMAssay Description:Inhibition constant against rat cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167289((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-methylhy...)
Affinity DataKi:  0.0770nMAssay Description:Inhibition constant against human cathepsin B in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167288((1S)-1-benzylpropyl 2-cyano-2-methylhydrazinecarbo...)
Affinity DataKi:  0.25nMAssay Description:Inhibition constant against human cathepsin B in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167290((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-isopropy...)
Affinity DataKi:  0.460nMAssay Description:Inhibition constant against human cathepsin H using L-Arg-b-naphthalamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TNNI3K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50578225(CHEMBL4869303)
Affinity DataKi:  0.540nMAssay Description:Binding affinity to full length human His-MBP-TNNI3K assessed as off-rate constant in presence of rhodamine green labeled GW805818X by fluorescence c...More data for this Ligand-Target Pair
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167290((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-isopropy...)
Affinity DataKi:  0.790nMAssay Description:Inhibition constant against human cathepsin L using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256480(CHEMBL466397 | N-(2,6-difluorophenyl)-5-(3-(2-(5-e...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to insulin receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167290((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-isopropy...)
Affinity DataKi:  1.30nMAssay Description:Inhibition constant against human cathepsin B in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167289((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-methylhy...)
Affinity DataKi:  1.40nMAssay Description:Inhibition constant against human cathepsin H using L-Arg-b-naphthalamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256480(CHEMBL466397 | N-(2,6-difluorophenyl)-5-(3-(2-(5-e...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to IGF1R by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50163832((1S)-2-cyclohexyl-1-methylethyl (2S)-1-cyanopyrrol...)
Affinity DataKi:  1.80nMAssay Description:Inhibition constant against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to insulin receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity to IGF1R by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TNNI3K(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50578225(CHEMBL4869303)
Affinity DataKi:  13nMAssay Description:Binding affinity to full length mouse His-MBP-TNNI3K assessed as off-rate constant in presence of rhodamine green labeled GW805818X by fluorescence c...More data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167297((Cyano-methyl-amino)-acetic acid (S)-2-cyclohexyl-...)
Affinity DataKi:  26nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167291(CHEMBL363610 | tert-butyl (2S)-1-cyanopyrrolidine-...)
Affinity DataKi:  60nMAssay Description:Inhibition constant against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167305((1S)-2-cyclohexyl-1-methylethyl 2-cyano-1,2-dimeth...)
Affinity DataKi:  62nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167292(2-(Cyano-methyl-amino)-N-((S)-2-cyclohexyl-1-methy...)
Affinity DataKi:  830nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167297((Cyano-methyl-amino)-acetic acid (S)-2-cyclohexyl-...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition constant against human cathepsin L using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167304((1S)-2-cyclohexyl-1-methylethyl 2-tert-butyl-2-cya...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50095495(CHEMBL262697 | Pyrrolidine-1-carbonitrile)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition constant against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167294((S)-2-(Cyano-methyl-amino)-propionic acid (S)-2-cy...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167297((Cyano-methyl-amino)-acetic acid (S)-2-cyclohexyl-...)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibition constant against human cathepsin B in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167299(CHEMBL191367 | Cyanomethyl-carbamic acid (S)-2-cyc...)
Affinity DataKi:  7.90E+3nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167300(((R)-Cyano-methyl-methyl)-carbamic acid (S)-2-cycl...)
Affinity DataKi: >1.30E+4nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167297((Cyano-methyl-amino)-acetic acid (S)-2-cyclohexyl-...)
Affinity DataKi: >1.30E+4nMAssay Description:Inhibition constant against human cathepsin H using L-Arg-b-naphthalamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167293((R)-2-(Cyano-methyl-amino)-propionic acid (S)-2-cy...)
Affinity DataKi: >1.30E+4nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167301(((S)-Cyano-methyl-methyl)-carbamic acid (S)-2-cycl...)
Affinity DataKi: >1.30E+4nMAssay Description:Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50163831((2S)-1-cyclohexylpropan-2-yl 1-cyanoazetidine-2-ca...)
Affinity DataIC50:  0.0480nMAssay Description:Inhibitory concentration against human cathepsin K using 10 uM Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50607602(CHEMBL5220994)
Affinity DataIC50:  0.0794nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50607596(CHEMBL5221053)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50084655(CHEMBL92708 | Calpeptin | Z-Leu-Nle-CHO | [(S)-1-(...)
Affinity DataIC50:  0.110nMAssay Description:Inhibiory activity against recombinant human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50607597(CHEMBL5219157)
Affinity DataIC50:  0.126nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50148310(((S)-1-Formyl-pentyl)-carbamic acid (S)-1-benzyl-p...)
Affinity DataIC50:  0.130nMAssay Description:Inhibitory concentration against human cathepsin K using 10 uM Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50148310(((S)-1-Formyl-pentyl)-carbamic acid (S)-1-benzyl-p...)
Affinity DataIC50:  0.130nMAssay Description:Inhibitory concentration against recombinant human cathepsin K determined in a fluorescence assay using 10 microM Cbz-Phe-Arg-AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50607595(CHEMBL5219030)
Affinity DataIC50:  0.158nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50607593(CHEMBL5219693)
Affinity DataIC50:  0.158nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50607601(CHEMBL5219667)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396542(CHEMBL2171141)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of GST tagged PERK cytoplasmic domain mediated EIF2alpha phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396536(CHEMBL2171122)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of GST tagged PERK cytoplasmic domain mediated EIF2alpha phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 2196 total ) | Next | Last >>
Jump to: