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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50057554
Substrate
n/a
Meas. Tech.
ChEMBL_158753 (CHEMBL772766)
IC50
5±n/a nM
Citation
 Penning, TD; Talley, JJ; Bertenshaw, SR; Carter, JS; Collins, PW; Docter, S; Graneto, MJ; Lee, LF; Malecha, JW; Miyashiro, JM; Rogers, RS; Rogier, DJ; Yu, SS; AndersonGD, na; Burton, EG; Cogburn, JN; Gregory, SA; Koboldt, CM; Perkins, WE; Seibert, K; Veenhuizen, AW; Zhang, YY; Isakson, PC Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J Med Chem 40:1347-65 (1997) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_HUMAN | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Enzyme
Mol. Mass.:
68692.62
Organism:
Homo sapiens (Human)
Description:
P23219
Residue:
599
Sequence:
MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
  
Inhibitor
Name:
BDBM50057554
Synonyms:
1,5-Bis-(4-methoxy-phenyl)-3-trifluoromethyl-1H-pyrazole | CHEMBL29204
Type:
Small organic molecule
Emp. Form.:
C18H15F3N2O2
Mol. Mass.:
348.3191
SMILES:
COc1ccc(cc1)-c1cc(nn1-c1ccc(OC)cc1)C(F)(F)F
Structure:
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