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Target
5-lipoxygenase
Ligand
BDBM50060881
Substrate
n/a
Meas. Tech.
ChEMBL_157766 (CHEMBL767669)
IC50
4000±n/a nM
Citation
 Müller, K; Prinz, H; Gawlik, I; Ziereis, K; Huang, HS Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem 40:3773-80 (1997) [PubMed]  Article 
Target
Name:
5-lipoxygenase
Synonyms:
Arachidonate 5-lipoxygenase
Type:
PROTEIN
Mol. Mass.:
49994.23
Organism:
Bos taurus
Description:
ChEMBL_157766
Residue:
430
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGDIQLIKIEKRKYWFHDDWYLKYITVKTPCGDYIEFPCYRWISGEGEIVLRDGQAKLACDDQIHVLKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWSDFADFEKIFVRISNTISERVMNHWQEDRMFGYQFLNGCNPVMIQRCLKLPDNLPVTTEMVECSLERQLTLEQEIEQGNIFIVDFKLLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQVPGEENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICEYGLFDKANATGG
  
Inhibitor
Name:
BDBM50060881
Synonyms:
10-Benzoyl-1,8-dihydroxy-10H-anthracen-9-one | CHEMBL123724
Type:
Small organic molecule
Emp. Form.:
C21H14O4
Mol. Mass.:
330.3335
SMILES:
Oc1cccc2C(C(=O)c3ccccc3)c3cccc(O)c3C(=O)c12
Structure:
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